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SCIENTIFIC ARTICLES
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Translational biomedical informatics in the cloud: present and future.Chen J, Qian F, Yan W, Shen B. Biomed Res Int. 2013;2013:658925. doi: 10.1155/2013/658925. Epub 2013 Mar 17.
New Approaches in Data Integration for Systems Chemical Biology.
Seoane JA, López-Campos G, Dorado J, Martin-Sanchez F. Curr Top Med Chem. 2013 Mar 1;13(5):591-601.
The Impact of Computer Science in Molecular Medicine: Enabling High-throughput Research.
de la Iglesia D, García-Remesal M, de la Calle G, Kulikowski C, Sanz F, Maojo V. Curr Top Med Chem. 2013 Mar 1;13(5):526-75.
The human gene connectome as a map of short cuts for morbid allele discovery. Itan Y, Zhang SY, Vogt G, Abhyankar A, Herman M, Nitschke P, Fried D, Quintana-Murci L, Abel L, Casanova JL.
Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5558-63. doi: 10.1073/pnas.1218167110. Epub 2013 Mar 18.
Personal genotypes are teachable moments. Boguski MS, Boguski RM, Berman MR. Genome Med. 2013 Mar 19;5(3):22. [Epub ahead of print]
(De)Personalized
medicine. Horwitz RI, Cullen MR, Abell J, Christian JB. Medicine. Science. 2013 Mar 8;339(6124):1155-6. doi: 10.1126/science.1234106.
Biomarker Discovery for Heterogeneous Diseases. Wallstrom G, Anderson KS, Labaer J. Cancer Epidemiol Biomarkers Prev. 2013 Mar 5. [Epub ahead of print]
Transforming Epidemiology for 21st Century Medicine and Public Health. Cancer Epidemiology Biomarkers & Prevention. Published Online First March 5, 2013; doi: 10.1158/1055-9965.EPI-13-0146 Cancer Epidemiol Biomarkers Prev April 2013 22; 508
Data re-identification:
societal safeguards. Altman RB, Clayton EW, Kohane IS, Malin BA, Roden DM. Science. 2013 Mar 1;339(6123):1032-3. doi:
10.1126/science.339.6123.1032-c.
Predicting drug efficacy using
integrative models for chronic respiratory diseases. Inflamm Allergy Drug Targets. Stevenson CS, Sridhar S, Phillips JE. 2013 Mar 19. [Epub ahead of print]
Pharmacogenomics and genome-wide association
studies. Hakonarson H. Ask the Experts: Pharmacogenomics. 2013 Mar;14(4):365-8. doi: 10.2217/pgs.13.16.
Big biology: The ´omes puzzle. Monya Baker. Volume 494 Number 7438 Nature (28 February 2013) DOI: doi:10.1038/494416a.
Complementary ensemble clustering of biomedical data.Fodeh SJ, Brandt C, Luong TB, Haddad A, Schultz M, Murphy T, Krauthammer M. J Biomed Inform. 2013 Feb 27. doi:pii: S1532-0464(13)00021-X. 10.1016/j.jbi.2013.02.001. [Epub ahead of print]
Processes for incorporation of
pharmacogenetic tests and interpretations in medical records for clinical
practice. Stocco G, Franca R, Londero M, Decorti G. Pharmacogenomics. 2013 Feb;14(3):236-7.
People, organizational, and
leadership factors impacting informatics support for clinical and translational
research. Payne PR, Pressler TR, Sarkar IN, Lussier Y. BMC Med Inform Decis Mak. 2013 Feb 6;13:20. doi:
10.1186/1472-6947-13-20.
Enabling
Genomic-Phenomic Association Discovery without Sacrificing Anonymity. Heatherly RD, Loukides G, Denny JC, Haines JL, Roden DM, Malin BA. PLoS One. 2013;8(2):e53875. doi: 10.1371/journal.pone.0053875. Epub 2013 Feb 6.
Biomedical informatics for computer-aided
decision support systems: a survey. Belle A, Kon MA, Najarian K. ScientificWorldJournal. 2013;2013:769639.
doi: 10.1155/2013/769639. Epub 2013 Feb 4.
Knowledge-based navigation system for building health diagnosis. Chih-Yuan Chang, Ming-Da Tsai. Science Direct 2013 Jan;doi: 10.1016/j.aei.2012.12.003.
How bioinformatics influences health informatics: usage of biomolecular sequences, expression profiles and automated microscopic image analyses for clinical needs and public health. Kuznetsov V, Lee Hwee K, Maurer-Stroh S, Molnár MJ, Pongor S, Eisenhaber B, Eisenhaber F. Health Information Science and Systems 2013, 1:2 doi:10.1186/2047-2501-1-2.
The emerging field of chemo- and pharmacoproteomics. Hess S. Proteomics Clin
Appl. 2013 Jan;7(1-2):171-80. doi: 10.1002/prca.201200091.
Personal genomic measurements: the opportunity for information integration. Altman RB. Clin Pharmacol Ther. 2013 Jan;93(1):21-3. doi: 10.1038/clpt.2012.203.
Clinical practice on the horizon: personalized medicine. Chadwell K. Clin Nurse Spec. 2013 Jan;27(1):36-43. doi: 10.1097/NUR.0b013e318277703c.
Genomic medicine: new frontiers and new challenges. Pasic MD, Samaan S, Yousef GM. Clin Chem. 2013 Jan;59(1):158-67. doi: 10.1373/clinchem.2012.184622.
Enabling high-throughput genotype-phenotype associations in the epidemiologic
architecture for genes linked to environment (eagle) project as part of the
population architecture using genomics and epidemiology (page) study.
Bush WS, Boston J, Pendergrass SA, Dumitrescu L, Goodloe R, Brown-Gentry K,
Wilson S, McClellan B, Torstenson E, Basford MA, Spencer KL, Ritchie MD, Crawford
DC. Pac Symp Biocomput. 2013:373-84.
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and data mining for biomedical discovery. Gonzalez G, Cohen KB, Greene CS, Hahn U, Kann MG, Leaman R, Shah N, Ye J.Pac Symp Biocomput. 2013:368-72.
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Translational Bioinformatics. PLOS Computational Biology .
Chapter 13: Mining Electronic Health Records in the Genomics Era. Denny J.C.
PLOS Computational Biology. 8 (12): e1002823.
Comparative interaction networks: bridging
genotype to phenotype. Beltrao P, Ryan C, Krogan NJ. CAdv Exp Med Biol. 2012;751:139-56. doi:
10.1007/978-1-4614-3567-9_7.
Advances in
translational bioinformatics and population genomics in the Asia-Pacific. BMC
Genomics. Ranganathan S, Tongsima S, Chan J, Tan TW, Schönbach C. 2012;13 Suppl 7:S1. doi: 10.1186/1471-2164-13-S7-S1. Epub 2012 Dec 13.
Translational research: the changing landscape of drug discovery. Fishburn CS.
Drug Discov Today. 2012 Dec 13. doi: 10.1016/j.drudis.2012.12.002.
Future prospects for pharmacogenetics in the quest for
personalized medicine. Howland RH. J Psychosoc Nurs Ment Health Serv. 2012 Dec;50(12):13-6.
Reply to ´Mining electronic health records: an additional perspective´. Jensen PB, Jensen LJ, Brunak S.
Nat Rev Genet. 2012 Dec 18;14(1):75. doi: 10.1038/nrg3208-c2.
Applying semantic web technologies for phenome-wide scan using an electronic health record linked Biobank. Pathak J, Kiefer RC, Bielinski SJ, Chute CG.
Journal of Biomedical semantics. 2012 Dec 17;3(1):10. doi: 10.1186/2041-1480-3-10.
Time to integrate clinical and research informatics.
Katzan IL, Rudick RA. Sci Transl Med. 2012 Nov 28;4(162):162fs41. doi: 10.1126/scitranslmed.3004583.
Comment to the article "Time to…."
Authors´ response
Systems pharmacology to predict drug toxicity:
integration across levels of biological organization. Bai JP, Abernethy DR. Annu Rev Pharmacol Toxicol.
2013;53:451-73. doi: 10.1146/annurev-pharmtox-011112-140248. Epub 2012 Nov 5.
Systems biology of complex symptom profiles:
capturing interactivity across behavior, brain and immune regulation. Broderick G, Craddock TJ. Brain Behav Immun. 2013 Mar;29:1-8. doi: 10.1016/j.bbi.2012.09.008. Epub 2012 Sep 28
A clinician-driven automated system for integration of pharmacogenetic interpretations into an electronic medical record. Hicks JK, Crews KR, Hoffman JM, Kornegay NM, Wilkinson MR, Lorier R, Stoddard A, Yang W, Smith C, Fernandez CA, Cross SJ, Haidar C, Baker DK, Howard SC, Evans WE, Broeckel U, Relling MV. Clin Pharmacol Ther. 2012 Nov;92(5):563-6. doi: 10.1038/clpt.2012.140. Epub 2012 Sep 19.
Toward mapping the biology of the genome. C hanock S. Genome Res. 2012 Sep;22(9):1612-5. doi: 10.1101/gr.144980.112.
Translational bioinformatics in psychoneuroimmunology: methods and
applications. Yan Q. Methods Mol Biol. 2012;934:383-400. doi:10.1007/978-1-62703-071-7_20.
Next-generation phenotyping of electronic health records. Hripcsak G, Albers DJ.
J Am Med Inform Assoc. doi:10.1136/amiajnl-2012-001145.
Clinical decision support for genetically guided personalized medicine: a systematic review. Welch, B. M., Kawamoto, K.
J Am Med Inform Assoc. doi:10.1136/amiajnl-2012-000892.
The UCSC genome browser and associated tools. Kuhn, R. M., Haussler, D., Kent, W. J., Briefings in Bioinformatics. 2012 Aug 20.
Roadmap to personalized medicine.
Qattan M, Demonacos C, Krstic-Demonacos M. Croat Med J. 2012 Aug;53(4):294-7.
The BioIntelligence Framework: a new computational platform for biomedical knowledge computing. Farley T, Kiefer J, Lee P, et al. J Am Med Inform Assoc 2012, Aug 2. doi:10.1136/amiajnl-2011-000646.
Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics. Valencia A, Hidalgo M. Genome Med. 2012 Jul 30;4(7):61.
Data Sharing and Publishing in the Field of Neuroimaging.
Breeze et al. GigaScience 2012, 1:9 (12 July 2012).
AMIA Board white paper: definition of biomedical informatics and specification of core competencies for graduate education in the discipline.
Kulikowski CA, Shortliffe EH, Currie LM, Elkin PL, Hunter LE, Johnson TR, Kalet IJ, Lenert LA, Musen MA, Ozbolt JG, Smith JW, Tarczy-Hornoch PZ, Williamson JJ.
J Am Med Inform Assoc. 2012 Jun 21.
Mining electronic health records: towards better research applications and clinical care. Jensen PB, Jensen LJ, Brunak S. Nat Rev Genet. 2012 May 2;13(6):395-405. doi: 10.1038/nrg3208.
Re-inventing Clinical Trials: Electronic Data Capture. Sansom C, Shublaq N (2012). Nature Biotech (in press).
Bringing Medical Data into Research: the Next Decade. Shublaq N, Coveney P (2012).Studies in Health Technologies and Informatics (in press).
Translational semantics and infrastructure: another search for the emperor's new clothes? Mullane K, Williams M. Drug Discov Today. 2012 May;17(9-10):459-68.
The 1000 Genomes Project: data management and community access. Laura Clarke, Xiangqun Zheng-Bradley, Richard Smith, Eugene Kulesha, Chunlin Xiao, Iliana Toneva, Brendan Vaughan, Don Preuss, Rasko Leinonen, Martin Shumway, Stephen Sherry, Paul Flicek & The 1000 Genomes Project Consortium. Nature Methods . Vol.9 N°.5. May 2012.
Merging genomic and phenomic data for research and clinical impact. Shublaq NW, Coveney PV. Stud Health Technol Inform. 2012;174:111-5.
Translational Bioinformatics: Linking the Molecular World to the Clinical World. Altman RB. Clin Pharmacol Ther. 2012 May 2. doi: 10.1038/clpt.2012.49. [Epub ahead of print]
Automatic filtering and substantiation of drug safety signals. Bauer-Mehren A, van Mullingen EM, Avillach P, Carrascosa MC, Garcia-Serna R, Piñero J, Singh B, Lopes P, Oliveira JL, Diallo G, Ahlberg Helgee E, Boyer S, Mestres J, Sanz F, Kors JA, Furlong LI. PLoS Comput Biol. 2012 Apr;8(4):e1002457. 2012 Apr 5. [Epub]
Network biology methods integrating biological data for translational science. Bebek G, Koyutürk M, Price ND, Chance MR. Brief Bioinform. 2012 Mar 5. [Epub]
Nanoinformatics: developing new computing applications for nanomedicine. Maojo, V., Fritts, M., Martin-Sanchez, F., De la Iglesia, D., Cachau, R., Garcia-Remesal, M., Crespo, J., Mitchell, J.A., Anguita, A., Baker, N., Barreiro, J., Benitez, S., De la Calle, G., Facelli, J., Ghazal, P., Geissbuhler, A., Gonzalez-Nilo, F., Graf, N., Grangeat, P., Hermosilla, I., Hussein, R., Kern, J., Koch, S., Legre, Y., Lopez-Alonso, V., Lopez-Campos, G., Milanesi, L., Moustakis, V., Munteanu, C., Otero, P., Pazos, A., Perez-Rey, D., Potamias, G., Sanz, F., Kulikowski, C. (2012). Computing. (March 7, 2012), 1-19.
Knowledge engineering for health: A new discipline required to bridge the 'ICT Gap' between research and healthcare. Beck T, Gollapudi S, Brunak S, Graf N, Lemke HU, Dash D, Buchan I, Díaz C, Sanz F, Brookes AJ. Human Mutation. 2012 Mar 5. doi: 10.1002/humu.22066. [Epub]
Biomedical Informatics Publications: a Global Perspective. Part II: Journals. Maojo V, García-Remesal M, Bielza C, Crespo J, Perez-Rey D, Kulikowski C. Methods Inf Med. 2012;51(2). Methods Inf Med. 2012 Mar 15;51(2):131-7.
Biomedical informatics publications: a global perspective: part I: conferences. Maojo V, García-Remesal M, Bielza C, Crespo J, Perez-Rey D, Kulikowski C. Methods Inf Med. 2012 Jan 10;51(1):82-90.
Personal Omics Profiling Reveals Dynamic Molecular and Medical Phenotypes. Rui Chen, George I. Mias, Jennifer Li-Pook-Than, Lihua Jiang, Hugo Y.K. Lam, Rong Chen, Elana Miriami, Konrad J. Karczewski, Manoj Hariharan, Frederick E. Dewey, Yong Cheng, Michael J. Clark, Hogune Im, Lukas Habegger, Suganthi Balasubramanian, Maeve O’Huallachain, Joel T. Dudley, Sara Hillenmeyer, Rajini Haraksingh, Donald Sharon, Ghia Euskirchen, Phil Lacroute, Keith Bettinger, Alan P. Boyle, Maya Kasowski, Fabian Grubert, Scott Seki, Marco Garcia, Michelle Whirl-Carrillo, Mercedes Gallardo, Maria A. Blasco, Peter L. Greenberg, Phyllis Snyder, Teri E. Klein, Russ B. Altman, Atul J. Butte, Euan A. Ashley, Mark Gerstein, Kari C. Nadeau, Hua Tang, and Michael Snyder. Cell 148, 1293–1307, March 16, 2012.
A translational engine at the national scale: informatics for integrating biology and the bedside. Kohane IS, Churchill SE, Murphy SN. J Am Med Inform Assoc. 2012 Mar 1;19(2):181-5.
iDASH: integrating data for analysis, anonymization, and sharing. Ohno-Machado L, Bafna V, Boxwala AA, Chapman BE, Chapman WW, Chaudhuri K, Day ME, Farcas C, Heintzman ND, Jiang X, Kim H, Kim J, Matheny ME, Resnic FS, Vinterbo SA; and the iDASH team. J Am Med Inform Assoc. 2012 Mar 1;19(2):196-201.
Using systems and structure biology tools to dissect cellular phenotypes. Floratos A, Honig B, Pe'er D, Califano A. J Am Med Inform Assoc. 2012 Mar 1;19(2):171-5.
The NIH National Center for Integrative Biomedical Informatics (NCIBI). Athey BD, Cavalcoli JD, Jagadish HV, Omenn GS, Mirel B, Kretzler M, Burant C, Isokpehi RD, Delisi C; the NCIBI faculty, trainees, and staff. J Am Med Inform Assoc. 2012 Mar 1;19(2):166-170.
Incorporating personalized gene sequence variants, molecular genetics knowledge, and health knowledge into an EHR prototype based on the Continuity of Care Record standard. Jing X, Kay S, Marley T, Hardiker NR, Cimino JJ. J Biomed Inform. 2012 Feb;45(1):82-92.
INBIOMEDvision: Promoting and Monitoring Biomedical Informatics in Europe. Shublaq N, Sanz F. The Virtual Physiological Human Network of Excellence Newsletter. 2012 Jan. Issue 7:21-23.
eTOC for First 2012 Issue of International Journal of Medical Informatics: Volume 81, Issue 1 (January 2012).
NEW: network-enabled wisdom in biology, medicine, and health care. Schadt EE, Björkegren JL. Sci Transl Med. 2012 Jan 4;4(115):115rv1.
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"Omics" and Biomedical Informatics: The Future of Pathology and Pathology Informatics. But, are we Ready for the Future?. Wong MC, Udayan R, Yee KC. Indian J Clin Biochem. 2011 Jul;26(3):217-21. Epub 2011 Jul 23.
Integration of diverse data sources for prediction of adverse drug events. Abernethy DR, Bai JP, Burkhart K, Xie HG, Zhichkin P (2011). Clin Pharmacol Ther, 90(5):645-646.
Empowering industrial research with shared biomedical vocabularies. Harland L, Larminie C, Sansone SA, Popa S, Marshall MS, Braxenthaler M, Cantor M, Filsell W, Forster MJ, Huang E, Matern A, Musen M, Saric J, Slater T, Wilson J, Lynch N, Wise J, Dix I (2011). Drug Discov Today.16(21-22):940-947.
The reductionist paradox: are the laws of chemistry and physics sufficient for the discovery of new drugs? Maggiora GM (2011). J Comput Aided Mol Des. 25(8):699-708.
Using Electronic Patient Records to Discover Disease Correlations and Stratify Patient Cohorts. Roque FS, Jensen PB, Schmock H, Dalgaard M, Andreatta M, Hansen T, Søeby K, Bredkjær S, Juul A, Werge T, Jensen LJ, Brunak S (2011). PLoS Comput Biol. 7(8):e1002141.
Biomedical informatics: how we got here and where we are headed. Ohno-Machado L. (2011) J Am Med Inform Assoc. 18(4):351.
Facilitating pharmacogenetic studies using electronic health records and natural-language processing: a case study of warfarin. Xu H, Jiang M, Oetjens M, Bowton EA, Ramirez AH, Jeff JM, Basford MA, Pulley JM, Cowan JD, Wang X, Ritchie MD, Masys DR, Roden DM, Crawford DC, Denny JC. (2011) J Am Med Inform Assoc. 18(4):387-91.
Computationally translating molecular discoveries into tools for medicine: translational bioinformatics articles now featured in JAMIA. Butte AJ, Shah NH (2011) J Am Med Inform Assoc 18(4):352-3.
Mapping clinical phenotype data elements to standardized metadata repositories and controlled terminologies: the eMERGE Network experience. Pathak J, Wang J, Kashyap S, Basford M, Li R, Masys DR, Chute CG (2011). J Am Med Inform Assoc 18(4):376-86.
2010 translational bioinformatics year in review. Altman RB, Miller KS (2011). J Am Med Inform Assoc.18(4):358-66.
dbGaP Data Access Requests: A Call for Greater Transparency. Walker L, Starks H, West KM, Fullerton SM. (2011) Sci Transl Med. 3(113):113.
Assessing and managing risk when sharing aggregate genetic variant data. Craig DW, Goor RM, Wang Z, Paschall J, Ostell J, Feolo M, Sherry ST, Manolio TA (2011). Nat Rev Genet. 12(10):730-766.
A Dimensional Bus model for integrating clinical and research data. Wade TD, Hum RC, Murphy JR. J Am Med Inform Assoc. 2011 Dec;18 Suppl 1:i96-i102.
Algorithms in nature: the convergence of systems biology and computational thinking. Navlakha S, Bar-Joseph Z. Mol Syst Biol. 2011 Nov 8;7:546.
Knowledge sharing and collaboration in translational research, and the DC-THERA Directory. Splendiani A, Gündel M, Austyn JM, Cavalieri D, Scognamiglio C, Brandizi M. 2011 Nov;12(6):562-75.
Tools and collaborative environments for bioinformatics research. Romano P, Giugno R, Pulvirenti A. 2011 Nov;12(6):549-61.
[Perspectives] From DNA to Targeted Therapeutics: Bringing Synthetic Biology to the Clinic. Chen YY, Smolke CD. Sci Transl Med. 2011 Oct 26;3(106):106ps42.
Systems medicine and integrated care to combat chronic noncommunicable diseases. Bousquet J, Anto JM, Sterk PJ, Adcock IM, Chung KF, Roca J, Agusti A, Brightling C, Cambon-Thomsen A, Cesario A, Abdelhak S, Antonarakis SE, Avignon A, Ballabio A, Baraldi E, Baranov A, Bieber T, Bockaert J, Brahmachari S, Brambilla C, Bringer J, Dauzat M, Ernberg I, Fabbri L, Froguel P, Galas D, Gojobori T, Hunter P, Jorgensen C, Kauffmann F, Kourilsky P, Kowalski ML, Lancet D, Pen CL, Mallet J, Mayosi B, Mercier J, Metspalu A, Nadeau JH, Ninot G, Noble D, Oztürk M, Palkonen S, Préfaut C, Rabe K, Renard E, Roberts RG, Samolinski B, Schünemann HJ, Simon HU, Soares MB, Superti-Furga G, Tegner J, Verjovski-Almeida S, Wellstead P, Wolkenhauer O, Wouters E, Balling R, Brookes AJ, Charron D, Pison C, Chen Z, Hood L, Auffray C. Genome Med. 2011 Jul 6;3(7):43.
Translational bioinformatics: linking knowledge across biological and clinical realms. Sarkar IN, Butte AJ, Lussier YA, Tarczy-Hornoch P, Ohno-Machado L. J Am Med Inform Assoc. 2011;18(4):354–357. doi: 10.1136/amiajnl-2011-000245. PubMed PMID: 21561873. Pubmed Central PMCID: 3128415. Epub 2011/05/13. eng.
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The $1,000 genome, the $100,000 analysis?. Elaine R Mardis. Genome Medicine 2010, 2:84.
Biomedical informatics and translational medicine. Sarkar IN. J Transl Med. 2010;8:22. doi: 10.1186/1479-5876-8-22. PubMed PMID: 20187952. Pubmed Central PMCID: 2837642. Epub 2010/03/02. eng.





